Novel Biomarkers FABP hsCRP MPO CK MB cTnT in young patient of Myocardial Infarction

Abstract

newline Abstract newlineMyocardial Infarction, usually referred to terms as a heart attack, is most often caused by a decreased or stoppage of blood flow to a portion of the heart, leading to necrosis of heart muscle. this is generally the result of a blood clot in the epicardial artery that supplies that territory of heart muscle. it is now recognized that, based on how AMI is defined, not all cases necessarily require a blood clot etiologically. In all living tissue such as heart muscle, the blood supply must equal the oxygen demands of the muscle. this is termed the supply-demand ration. It is now appreciated that an imbalance in this ratio ( too little supply or too much demand ) as might occur with very rapid heart rate (too much demand) or drop in blood pressure (too little supply ) may lead to Myocardial damage without the presence of a blood clot per se.(N1) this definition states that there must be a rise or fall (Or both) in blood test sensitive to heart muscle damage ( Troponin I and T ) with at least one value above the 99th percentile of the upper reference limit along with clinical evidence for diagnosis of AMI. This clinical evidence includes symptoms of ischemia, which include either ECG evidence indicative of ischemia such as ST segment changes or new left bundle block, development of pathological Q waves on ECG, or new wall motion abnormalities on cardiac testing or a combination of these. newlineIt began in the 1970s, when the World Health Organization (WHO) originally defined myocardial infarction as the presence of two of the three features listed below: (1,2). i) Acute ischemia symptoms (chest discomfort), ii) the appearance of Q waves on an electrocardiogram (ECG), and iii) a rise in enzymes in the blood [a combination of total creatine kinase (CK), CK-myocardial band (MB), AST, and lactate dehydrogenase (LDH)]. Later in 1999, a joint committee of the European Society of Cardiology and the American College of Cardiology recommended a new definition for myocardial infarction, highlighting the relev