Association of Serum Inflammatory Marker With Renal Markers and Lactate Dehydrogenase in Meconium Aspirate Patients

Abstract

newline Abstract newlineIntroduction: Meconium is the earliest stool of a newborn. Meconium aspiration syndrome (MAS) is a medical situation characterized by respiratory failure occurring in neonates born through meconium-stained amniotic fluid (MSAF). It is necessary to find out the factors associated with syndrome. Therefore, this study had been conducted to find out the correlation of the C-reactive protein with renal markers, spO2 and lactate dehydrogenase in meconium aspirate patients. newlineMaterial and methods: Total 100 diagnosed Meconium Aspirated patients were taken for this study. Serum CRP was estimated by Latex enhanced Nephelometery Method, Serum Urea was estimated by Urease Method, Serum Creatinine was be estimated by Jaffe s Method, Serum LDH was estimated by DGKC Method and SpO2 by Pulse Oximeter. newlineResult: In this study there was a positive correlation (P-value lt0.001) of CRP with serum urea levels, serum creatinine levels, serum LDH level and negative correlation (P-value lt0.001) with SpO2. newlineDiscussion and conclusion: Meconium Aspiration Syndrome (MAS) is respiratory distress in a newborn baby who requires neonatal intensive care units (NICU). Several studies had reported that inflammatory markers are closely associated with the disease. Quick and early detection is needed for early treatment and prognosis of disease. newlineKeywords: Meconium aspiration syndrome, CRP, LDH, Inflammation