Neuroprotective and nootropic effects of canarium strictum

Abstract

newline The neuroprotective activity of ECSL was found to have a significant impact on neuronal cell death triggered by hydrogen peroxide (MTT assay) in human SH-SY5Y neuroblastoma cells. Scopolamine, a muscarinic receptor blocker, is frequently used to induce cognitive impairment in laboratory animals. Injections of scopolamine influence multiple cognitive functions, including motor function, short-term memory, and attention. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, memory enhancing activity in scopolamine-induced amnesic rats was evaluated. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, ECSL was found to have a substantial effect on the memory of scopolamineinduced amnesic rats. Our experimental data indicated that ECSL can reverse scopolamine induced amnesia and assist with memory issues. Molecular Operating Environment software was used to do a docking investigation on the probable putative targets of the isolated chemical scopoletin as AChE inhibitors. Scopoletin exhibited considerable target docking and hydrogen bonding. Forecast the ADMET attributes of scopoletin using the Swiss ADMET web toll confirms that scopoletin exhibited favourable pharmacokinetic, physicochemical, lipophilicity, water solubility, pharmacological, and medicinal chemistry properties.