synthesis of medicinally important novel heterocyclic compounds and their applications

Abstract

Present work comprises of five chapters, It is introduced by first discussing medicinal and heterocyclic chemistry. Following that, hybrid molecules with two distinct modes of action are also listed here. This chapter also covered the introduction of Ultrasound Sonochemistry, Multicomponent reactions, water as a green solvent and green chemistry as a source of long-term chemistry. newline Further chapter two and three emphasizes one pot multi-component synthesis of oxygen containing heterocyclic compounds via ultrasonic irradiation were synthesized under ultrasonic irradiation using morpholine as a catalyst in aqueous condition. The synthesized titled derivatives were confirmed by IR, 1H NMR, 13C NMR, mass spectra and their spectral characterization are furnished here. Water as green solvent, is used in the synthesis. The ultrasound assisted synthesis and characterization of 2-amino-4H-chromene derivatives and 2-oxochromane derivatives are presented in chapter two and chapter three respectively. Moreover, an optimization study with different conditions was provided in this chapter. newline The present chapter four consists of conventional and microwave assisted multi-step synthesis of 1, 3, 4- oxadiazole derivatives and their spectral characterization. 1, 3, 4- oxadiazole derivatives are synthesized via four successive step. Step-I: Synthesis of 5-(pyridin-4-yl)-1,3,4-oxadiazole-2-thiol, Step-II: Synthesis of N-(3-acetylphenyl)-2-chloroacetamide, Step-III: Synthesis of 1-(3-((3-((5-(pyridin-4-yl)-4H-pyrazol-3-yl) thio)prop-1-en-2-yl)amino)phenyl)ethan-1-one and Step-IV: Synthesis of (Z)-N-(3-(3-phenylacryloyl)phenyl)-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio) acetamide which is final derivative of this reaction. newline Chapter 5 provided a biological assessment of the recently synthesised substances. All synthesised compounds are provided their antibacterial activity and SAR studies (Chapter-2 and Chapter-3). The synthesised compounds are tested using the Kirby-Bauer disc dif