Characterization and evaluation of small molecular bioactives and polysaccharides from the prominent marine macroalgae belonging to the classes Phaeophyceae and Florideophyceae

Abstract

newlineBioactive compounds from marine macroalgae are gaining immense attention for newlinetheir application as natural ingredients in various nutraceuticals and food supplements. In newlineIndia, marine algae have found their application not only in pharmaceuticals but also in newlineagriculture sectors. Among the varieties of abundantly available species in India, marine newlinealgae belonging to the classes Phaeophyceae and Florideophyceae were found to possess newlinepotential bioactive compounds. In particular, marine algae belonging to the subclasses newlineDictyotophycidae, Fucophycidae and Rhodymeniophycidae are underexplored species, newlinerequiring detailed studies. newlineThe present study evaluated the medicinal properties of the organic extracts of four newlinebrown and red marine macroalgal species, using various in vitro assays. Organic extracts of newlinebrown algae of Fucophycidan subclass, such as Sargassum plagiophyllum, Turbinaria newlinedecurrens, and red alga Hydropuntia edulis, Portieria hornemanii displayed potential newlineinhibitory properties against antioxidants (IC50 0.2 0.8 mg/mL) and carbolytic enzymes newline(IC50 0.2 0.9 mg/mL) compared to those exhibited by other studied algae. Noticeably, newlineorganic extracts of red alga H. edulis and brown alga T. decurrens could effectively attenuate newlinepro-inflammatory 5-lipoxygenase (IC50 0.4 0.6 mg/mL), thereby demonstrating their newlinepotential application to dissuade inflammatory pathogenesis.