1. Shodhganga@INFLIBNET
  2. Panjab University
  3. Department of Biochemistry
Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/509864
Title: Identification and characterization of a novel bacteriocin from microbial genome database
Researcher: Mangal Singh
Guide(s): Sareen, Dipiti
Keywords: Bacteriocin
Genome database
Lantibioticy
Microbial
Roseocin
University: Panjab University
Completed Date: 2017
Abstract: A class of bacteriocins known as lantibiotics, are small ribosomally synthesized and post translationally modified peptides (RiPPs) containing lanthionine rings. In this study, 24 novel putative lantibiotic biosynthetic gene clusters (BGCs) were identified from NCBI genome database. BGC of Streptomyces filamentosus NRRL 11379, encoding Roseocin was characterized by heterologous coexpressíon of the minimally required genes in E. coli. The lanthipeptides were purified to homogeneity, and characterized by mass spectrometry. Antimicrobial activity analysis of activated Roseocin established it to be a novel two component lantibiotic. newline
Pagination: 164p.
URI: http://hdl.handle.net/10603/509864
Appears in Departments:Department of Biochemistry

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01_title.pdfAttached File2.85 kBAdobe PDFView/Open
02_prelim pages.pdf1.81 MBAdobe PDFView/Open
03_chapter_1.pdf495.33 kBAdobe PDFView/Open
04_chapter_2.pdf430.92 kBAdobe PDFView/Open
05_chapter_3.pdf2.87 MBAdobe PDFView/Open
06_chapter_4.pdf3.14 MBAdobe PDFView/Open
07_chapter_5.pdf4.76 MBAdobe PDFView/Open
08_chapter_6.pdf590.43 kBAdobe PDFView/Open
09_annexure.pdf2.24 MBAdobe PDFView/Open
80_recommendation.pdf309.92 kBAdobe PDFView/Open
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