ADVANCED PHYTOPHARMACEUTICAL STUDIES ON SELECTED TRADITIONAL ANTIDIABETIC HERBAL FORMULATION

Abstract

Diabetes mellitus is a metabolic disorder in which a person has high blood sugar level because either the pancreas does not produce enough insulin or cells do not respond to it Diabetes mellitus is of three types Type one or Insulin Dependent Diabetes Mellitus IDDM Type two or Non Insulin Dependent Diabetes Mellitus NIDDM and Gestational Diabetes GD The Siddha system of medicine is the oldest traditional treatment system generated from Dravidian culture In Siddha system of medicine many single and polyherbal formulations and higher medicines like parpam chendooram and chunnam have been practiced to cure or control Diabetes mellitus from time immemorial Siddha polyherbal formulations like Seenthil Kudineer Seenthi Choornam Vilva kudineer Avarai kudineer Madhumegha choornam Navalkottai Choornam Silasathu parpam Abraka chendooram Triphala Choornam and the like are used in treatment of Diabetes mellitus Among the Siddha anti diabetic formulations Neerazhivu chooranam is a reputed and popular polyherbal formulation scientifically under explored This formulation suffers from patients non compliance because of cumbersome dosage form instability difficulty in dose selection and administration These disadvantages are overcome by formulating the same into a tablet and capsule dosage form Quality control parameters such as raw material standardization in processes and finished product quality control studies were carried out in this investigation Sophisticated modern instruments were used as an advanced tool in phytopharmaceutical evaluation of the selected polyherbal formulations so as to prescribe the quality standards for better therapeutic efficacy The toxicological evaluation of herbal drug ingredients like determination of pesticide residues heavy metal contamination and microbial contamination and their formulation Neerazhivu chooranam for acute toxicity studies using recent advanced analytical tools have been carried out in keen interest of uplifting the herbal drug to the global mark