Studies on optimization of sustained action gastroretentive dosage form for better control of gastric problem

Abstract

A novel floating drug delivery system of Curcumin was formulated in an effort to increase the gastric retention time of the dosage form and to control drug release. Among the drugs currently in clinical use are several narrow absorption windows, drugs that may benefit from compounding into floating drug delivery systems. Replacing parenteral administration of drugs to oral pharmacotherapy would substantially improve treatment. It is anticipated that floating drug delivery systems may enhance this possibility. newlineThese accumulated findings of warrant additional research on floating drug delivery system with natural polymer, which combine large dimensions with high rigidity to achieve prolonged gastro retentivity. Curcumin are anticancer drugs. These are widely prescribed in gastric ulcers, duodenal ulcers, and gastroesophageal inflammation disease leads to cancer. Curcumin has low bioavailability (47¡V56%) and short biological half-life (2.5-4 hrs) and Curcumin has short half life (2.00 hrs) and low bioavailability (50%), when oral administration this favors development of a floating drug delivery system to achieve controlled release. Thus, Curcumin were chosen as suitable drug candidates for floating drug delivery system. However this drug has been used to develop many gastro retentive drug delivery systems, but failure in many cases. As we have made an attempt to overcome the problems by utilizing suitable natural polymer and floatation approach. The focus will probably be on floating system as they permit the reduction of synthetic polymers, proper utilization of natural polymers as they have desirable properties. It could be possible to modify its characteristics by degree of deacetylation to achieve low density, swellability, to become more suitable to deliver the drugs through floating approach. newlineWith an increasing understanding of polymer behavior and the role of the biological factors mentioned above, it is proposed that future research work in the FDDS should be aimed at discovering means to contr