Development of Metal Oxide Based Two Dimensional Layered Materials for Non Enzymatic Electrochemical Detection of Glucose

Abstract

In this dissertation, we have proposed hybrid nanocomposites of NiO with various 2D Transitional metal dichalcogenides, i.e., MoS2, MoSe2 and WS2. The hybrid nanocomposites were later used as electrocatalysts for the detection of glucose. Prepared electrocatalysts were characterized by different physicochemical techniques. XRD confirmed the phase purity of prepared electrocatalyst. UV-Vis spectra were used for absorption studies. On the other hand, FESEM with EDAX / Elemental colour mapping and HRTEM was used for morphological analysis and elemental mapping. The information related to the oxidation state was observed using XPS. Additionally, the Surface area and pore size of the electrocatalyst was estimated using BET studies. For the electrochemical characterization and detection of glucose, techniques like cyclic voltammetry (CV), amperometry and impedance spectroscopy (EIS) were used. In the overall experiment, a glassy carbon electrode is used as a working electrode/substrate throughout the experiments. newlineInitially, the hydrothermal method was used to obtain NiO/MoS2 nanocomposites in powder form. After that, the NiO/MoS2 is drop cast onto a glassy carbon electrode (GCE). To detect glucose in a sodium hydroxide (0.1 M NaOH), the NiO/MoS2/GCE is used. EIS was used to investigate the charge transfer characteristic; as a result, we could conclude that NiO/MoS2/GCE had a lower charge transfer resistance when compared to NiO/GCE and MoS2/GCE. A thorough investigation of the redox behaviour of NiO/MoS2/GCE was carried out using CV. In addition, an amperometric test was performed using the modified GCE to determine the various glucose concentrations. Based on the findings, we noticed that the modified GCE covered a broad linear range of glucose concentration, which extended from 10 and#956;M to 10 mM at a fixed voltage of +0.55 V. It was determined that the limit of detection (LOD) was 1.62 and#956;M. An investigation on selectivity was carried out using common compounds that cause interference newline