Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/500168
Title: | The G protein coupled estrogen receptor in breast tumors positively associates with ERalpha and constitutes a clinically significant genomic target of estrogen in breast cancer cells |
Researcher: | Pal, Uttariya |
Guide(s): | Limaye, Anil Mukund |
Keywords: | Biotechnology and Applied Microbiology Life Sciences Microbiology |
University: | Indian Institute of Technology Guwahati |
Completed Date: | 2023 |
Abstract: | Estrogen exerts its effects on target cells, and tissues via genomic, and non-genomic pathways. The genomic effects of estrogen are mediated by the canonical estrogen receptors, namely ERand#945; and ERand#946;. These are ligand-dependent transcription factors encoded by the ESR1 and ESR2 genes, respectively. The non-genomic effects of estrogen are mediated by membrane-tethered canonical estrogen receptors, ERand#945;36, a splice variant of ERand#945;, or the non-canonical G-protein coupled estrogen receptor (GPER). |
Pagination: | |
URI: | http://hdl.handle.net/10603/500168 |
Appears in Departments: | DEPARTMENT OF BIOSCIENCES AND BIOENGINEERING |
Files in This Item:
File | Description | Size | Format | |
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01_fulltext.pdf | Attached File | 5.73 MB | Adobe PDF | View/Open |
04_abstract.pdf | 317.98 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 537.12 kB | Adobe PDF | View/Open |
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