Design Synthesis Characterization and Pharmacological Evaluation of Cannbaidiol Derivatives for Anticonvulsant Activity

Abstract

Cannabidiol is one of the major phyto-cannabinoids found in Cannabis sativa, distinguishing newlinefrom and#916;9-tetrahydrocannabinol (THC) for its non-intoxicating profile and its newlineantianxiety/antipsychotic effects. It is a multi-target drug with different mechanism of action. newlineIn view of this, for getting better antiepileptic activity with less side effects , a series of novel newlinecannabinoid derivatives (1-16) were synthesized by reaction of (S)-3-methyl-6-(prop-1-en-2- newlineyl) cyclohex-2-enol and various intermediates (1, 2, 3, 4, 5, 6, 9 and 12) in the presence of newlineboron trifluoride. First (+) Limonene was converted into (S)-3-methyl-6-(prop-1-en-2-yl) newlinecyclohex-2-enone which was further reduced to (S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-2- newlineenol and finally reacted with respective intermediates to form final novel Cannabinoid newlinederivates. newlineThe final compounds were synthesized in moderate to good yield. Synthesized newlinecompounds were physiochemically characterized by the determination of M.P, B.P, Rf and % newlineyield. The structures were confirmed and spectrally characterized by IR, 1H and 13 C NMR, newlineMass spectral data and their purity was established by elemental analysis. The compounds newlinewere purified by silica gel column chromatography after last step of synthesis by using newlineMobile Phase: Ethylacetate: Hexane (1:4) and detection was done by UV and KMnO4. newlineFurther these compounds will be pharmacologically evaluated for anti-convulsant activity newline