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http://hdl.handle.net/10603/489709
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DC Field | Value | Language |
---|---|---|
dc.coverage.spatial | Pharmacy | |
dc.date.accessioned | 2023-06-07T08:47:00Z | - |
dc.date.available | 2023-06-07T08:47:00Z | - |
dc.identifier.uri | http://hdl.handle.net/10603/489709 | - |
dc.description.abstract | x newlineABSTRACT newlineAIMS newlineTo characterize pharmacokinetic (PK) variability of risperidone and 9-OH risperidone newlineusing sparse sampling and to evaluate the effect of covariates on PK parameters. newlineMETHODS newlinePK analysis used plasma samples collected from the Clinical Anti-psychotic Trials of newlineIntervention Effectiveness. A nonlinear mixed-effects model was developed using newlineNONMEM to describe simultaneously the risperidone and 9-OH risperidone newlineconcentration time profile. Covariate effects on risperidone and 9-OH risperidone PK newlineparameters were assessed, including age, weight, sex, smoking status, race and newlineconcomitant medications. newlineRESULTS newlinePK samples comprised risperidone and 9-OH risperidone concentrations from 20 newlinesubjects that were available for analysis. Ages ranged from 18 to 93 years. Population newlinePK submodels for both risperidone and 9-OH risperidone with first-order absorption newlinewere selected to describe the concentration time profile of risperidone and 9-OH newlinerisperidone. A mixture model was incorporated with risperidone clearance (CL) newlineseparately estimated for three subpopulations [poor metabolizer (PM), extensive newlinemetabolizer (EM) and intermediate metabolizer (IM)]. Age significantly affected 9-OH newlinerisperidone clearance. Population parameter estimates for CL in PM, IM and EM were newline12.9, 36 and 65.4 l h-1 and parameter estimates for risperidone half-life in PM, IM and newlineEM were 25, 8.5 and 4.7 h, respectively. newlineCONCLUSIONS newlineA one-compartment mixture model with first-order absorption adequately described newlinethe risperidone and 9-OH risperidone concentrations. Age was identified as a newlinesignificant covariate on 9-OH risperidone clearance in this study. newline | |
dc.format.extent | XXI, 151 | |
dc.language | English | |
dc.relation | ||
dc.rights | university | |
dc.title | Population pharmacokinetic studies of various drugs used in CNS related diseases in south Indian patients | |
dc.title.alternative | ||
dc.creator.researcher | Bootam, Sharath Babu | |
dc.subject.keyword | Cardiac and Cardiovascular Systems | |
dc.subject.keyword | Clinical Medicine | |
dc.subject.keyword | Clinical Pre Clinical and Health | |
dc.subject.keyword | CNS related diseases | |
dc.subject.keyword | Pharmacokinetic | |
dc.subject.keyword | South Indian patients | |
dc.description.note | ||
dc.contributor.guide | Kannadhasan, R. and Babu, G. Sridhar | |
dc.publisher.place | Chittorgarh | |
dc.publisher.university | Mewar University | |
dc.publisher.institution | Department of Pharmacy | |
dc.date.registered | 2017 | |
dc.date.completed | 2022 | |
dc.date.awarded | 2022 | |
dc.format.dimensions | ||
dc.format.accompanyingmaterial | CD | |
dc.source.university | University | |
dc.type.degree | Ph.D. | |
Appears in Departments: | Department of Pharmacy |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 83.09 kB | Adobe PDF | View/Open |
02_prelim pages.pdf | 822.02 kB | Adobe PDF | View/Open | |
03_abstract.pdf | 98.14 kB | Adobe PDF | View/Open | |
04_contents.pdf | 163.58 kB | Adobe PDF | View/Open | |
05_chapter 1.pdf | 189.21 kB | Adobe PDF | View/Open | |
06_chapter 2.pdf | 162.09 kB | Adobe PDF | View/Open | |
07_chapter 3.pdf | 233.27 kB | Adobe PDF | View/Open | |
08_chapter 4.pdf | 125.42 kB | Adobe PDF | View/Open | |
09_chapter 5.pdf | 157.33 kB | Adobe PDF | View/Open | |
10_chapter 6.pdf | 460 kB | Adobe PDF | View/Open | |
11_chapter 7.pdf | 1.08 MB | Adobe PDF | View/Open | |
12_chapter 8.pdf | 221.66 kB | Adobe PDF | View/Open | |
13_chapter 9.pdf | 177.37 kB | Adobe PDF | View/Open | |
14_chapter 10.pdf | 171.84 kB | Adobe PDF | View/Open | |
15_annexures.pdf | 1.93 MB | Adobe PDF | View/Open | |
80_recommendation.pdf | 260.23 kB | Adobe PDF | View/Open |
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