Variation in Jathragni its impact on serum bile acids and effect of Agnivardhak Yoga on serum bile acids

Abstract

ABSTRACT newlineIntroduction: - Agni is the key factor responsible for all digestive activities and vital functions in the body. Balanced Agni is indicator of health, whereas vitiated Agni disturbs digestion resulting in ill health. Hence, Agni is said to be the base of life. Agni and pitta are closely associated. Grahani is considered as Agni Adhishthan (location), Pitta is secreted in the Grahani which performs the function of digestion. So, Agni can be correlated with the contents of bile i.e., bile acids located in the Grahani region, which helps in digestion. newlineMethodology: - Study was conducted in two phases. newlinePhase I - In first phase total 34 participants (17 from Mandagni group and 17 from Samagni group) were randomly selected. Their subjective parameters- Agni, Prakruti, Koshtha and Mala as well as objective parameters serum bile acids (7- TCA, TDCA, GCA, CA, GCDCA, DCA and CDCA) were assessed and Statistical analysis of subjective parameters and objective parameters was done. newlinePhase II - In second phase Mandagni participants were given Hingwashtak Churna in the form of intervention with first morsel of the meals, twice a day for 15 days along with Anupana Goghrita and again assessment of subjective and objective parameters was done after 15 days and statistical analysis was done to compare the observations before and after intervention. newlineResults: - newlinePhase I- Mean of Serum BA (7) in Mandagni volunteers is (1.562 and#956;mol/lit) more as compared to Samagni (1.096 and#956;mol/lit) newlinePhase II- Mean quantity of Serum BA (7) in pre-Mandagni cases is 1.562and#956;mol/lit as compared to post-Mandagni cases 1.112 and#956;mol/lit, which is near to mean of the Samagni participants newlineConclusion: - newlinePhase I- There was Significant change in Agni status and mean serum bile acids in Samagni and Mandagni group. newlinePhase II- After using Hingwashtak Churna status of Agni was changed subjectively from Mand towards Sama. This can also be evident by changes in their mean Serum BA levels, which were nearly equal to the mean quantity of Serum BA (7) of Samagni cases. newlineKeywor