Synthesis and Characterization of Some Biological Important Heterocycles by Conventional and Non Conventional Methods

Abstract

The present work undertaken entitled Synthesis and Characterization of Some newlineBiological Important Heterocycles by Conventional and Non-conventional Methods is newlinepresented in six chapters and each chapter (from chapter II to V) is subdivided in to three section newlineA, B and C. The chapter wise summary is given below. newlineCHAPTER-I newlineINTRODUCTION newlineThe first part describes the general introduction and literature survey. newlineCHAPTER-II newlineSYNTHESIS OF 2, 4, 5-TRIPHENYLIMIDAZOLE DERIVATIVES And newlineSYNTHESIS OF 5-ARYLIDENE-2, 4-THIAZOLIDINEDIONES newlineIt is divided into three sections. newlineSECTION A newlineIn this section, 2, 4, 5-triphenylimidazole derivatives are prepared by reaction of newlinesubstitute benzaldehyde heterocyclic aldehydes, benzil/benzoin and ammonium acetate in newlinepresence of silicotungstic acid (STA) (7.5 mol %) as catalyst in ethanol solvent on reflux newline(Scheme-I). newlineScheme-I newlineSECTION B newlineIn this section, 2, 4, 5-triphenylimidazole derivatives are prepared by reaction of newlinesubstitute benzaldehyde heterocyclic aldehydes, benzil/benzoin and ammonium acetate in newlinepresence of L-Glutamic acid (10 mol %) catalyst in ethanol solvent on reflux (Scheme-II). newlineAbstract newlineB. P. Ankush 2 newlineScheme-II newlineSECTION C newlineIn this section we have studied, the synthesis of substituted 5-Benzylidenethiazolidine-2, newline4-dione derivatives from substituted benzaldehyde and thiazolidine-2, 4- dione in the presence of newlinecatalytic amount of tannic acid (10 mol %) in ethanol solvent at 80 °C temperature (Scheme-III). newlineScheme-III newlineCHAPTER-III newlineSYNTHESIS OF TETRAHYDROBENZO[b]PYRAN DERIVATIVES newlineIt is divided into three sections. newlineSECTION A newlineThis section deals with the synthesis of tetrahydrobenzo[b]pyran derivatives from newlinedifferent substituted benzaldehyde / heterocyclic aldehydes, dimedone and malononitrile by using newlinetannic acid (10 mol %) as catalyst in ethanol: water (1: 4) solvent on reflux (Scheme-IV). newlineScheme-IV newlineAbstract newlineB. P. Ankush 3 newlineSECTION B newlineIn this section, we have reported a facile and efficient methodology for the synthesis of newlinetetrahydrobenzo[b]pyran. This method involves the efficient synthesis of