Shodhganga : a reservoir of Indian theses @ INFLIBNET
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/485459
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.coverage.spatial | Parasitology | |
| dc.date.accessioned | 2023-05-24T11:37:26Z | - |
| dc.date.available | 2023-05-24T11:37:26Z | - |
| dc.identifier.uri | http://hdl.handle.net/10603/485459 | - |
| dc.description.abstract | The emergence of drug-resistant strains of Plasmodium spp. impede the progress of malaria eradication programs. Drug repurposing is a new approach to screen FDA approved drugs used for the treatment of other ailments as chemotherapeutic agents against malaria. In addition, synthetic compounds having chemical moiety akin to marketed drugs can be assessed against the parasite. Thus, the present study explores the antimalarial efficacy of tetrahydrobetacarboline derivative 9a, tyrosine kinase inhibitor gefitinib, phosphodiesterase inhibitor tadalafil along with bioavailability enhancer leucovorin. Gefitinib and 9a revealed substantial antimalarial activity against P. falciparum in vitro and P. berghei in vivo with plausible synergistic activity with artesunate. newline | |
| dc.format.extent | 310p. | |
| dc.language | English | |
| dc.relation | - | |
| dc.rights | university | |
| dc.title | Evaluation of antiplasmodial efficacy of some synthetic compounds and drugs | |
| dc.title.alternative | ||
| dc.creator.researcher | Gorki, Varun | |
| dc.subject.keyword | Drug designing and discovery | |
| dc.subject.keyword | Drug repurposing | |
| dc.subject.keyword | Malaria | |
| dc.subject.keyword | Plasmodium spp. | |
| dc.subject.keyword | Rationale based synthesis | |
| dc.description.note | Bibliography 225-310p. Annexure i-xp. | |
| dc.contributor.guide | Sukhbir Kaur | |
| dc.publisher.place | Chandigarh | |
| dc.publisher.university | Panjab University | |
| dc.publisher.institution | Department of Zoology | |
| dc.date.registered | 2015 | |
| dc.date.completed | 2022 | |
| dc.date.awarded | 2023 | |
| dc.format.dimensions | - | |
| dc.format.accompanyingmaterial | CD | |
| dc.source.university | University | |
| dc.type.degree | Ph.D. | |
| Appears in Departments: | Department of Zoology | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01_title.pdf | Attached File | 32.16 kB | Adobe PDF | View/Open Request a copy |
| 02_prelim pages.pdf | 1.44 MB | Adobe PDF | View/Open Request a copy | |
| 03_introduction.pdf | 259.53 kB | Adobe PDF | View/Open Request a copy | |
| 04_review of literature.pdf | 1.3 MB | Adobe PDF | View/Open Request a copy | |
| 05_materials and methods.pdf | 510.84 kB | Adobe PDF | View/Open Request a copy | |
| 06_results and observations.pdf | 6.84 MB | Adobe PDF | View/Open Request a copy | |
| 07_discussions.pdf | 195.85 kB | Adobe PDF | View/Open Request a copy | |
| 08_summary and conclusions.pdf | 201.08 kB | Adobe PDF | View/Open Request a copy | |
| 09_annexure.pdf | 2.12 MB | Adobe PDF | View/Open Request a copy | |
| 80_recommendation.pdf | 217.04 kB | Adobe PDF | View/Open Request a copy |
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