Suicide enzymes purification characterization and encapsulation for therapeutic implications

Abstract

Suicide gene therapy has been extensively investigated as an alternative approach to increase selectivity in cancer treatment The strategy involves transfer of suicide gene to tumor cells followed by administration of prodrug in which the transgene encodes enzyme that activates the prodrug to create toxic products and there by kill cancer cells In addition direct delivery of encapsulated suicide enzyme to cancer cells is another recent approach to activate prodrug Two main themes of my thes