Design and synthesis of esters as protein kinase c pkc ci domain regulators

Abstract

The contents of my thesis have been divided into six chapters based on the results of experimental work performed during the complete course of research period The introductory chapter chapter 1 of the thesis presents the structure activation and C1 domain of protein kinase C PKC In addition C1 domain targeted ligands including natural products synthetic compounds and the synthesis of biological active ester molecules using different approaches Chapter 2 describes design synthesis and