Molecular dynamics simulation studies on counteraction of temperature induced and urea conferred protein denaturation by trehalose molecules

Abstract

The osmolyte trehalose often used in pharmaceutical food and biomedical applications to prepare glassy matrices for long term storage of biological materials It is also used naturally by several organisms to survive from external stresses temperature change and or dehydration and chemical denaturation Despite its importance in bioprotection how does trehalose stabilize proteins and counter the temperature induced and urea conferred protein denaturation is one of the unsolved proble