Shodhganga : a reservoir of Indian theses @ INFLIBNET
The Shodhganga@INFLIBNET Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access.
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/482076
| Title: | Exploring leishmania biochemistry to understand effect of spermidine starvation and identification of novel drug candidates |
| Researcher: | Singh, Shalini |
| Guide(s): | Dubey, Vikash Kumar |
| Keywords: | Biotechnology and Applied Microbiology Life Sciences Microbiology |
| University: | Indian Institute of Technology Guwahati |
| Completed Date: | 2015 |
| Abstract: | Leishmaniasis is caused by different species of Leishmania In order to develop a better drug candidate we chose to explore two different pathways of Leishmania redox metabolism and protein prenylation pathway Spermidine synthase a key enzyme for second step of redox metabolism pathway of parasite catalyzes formation of spermidine We have identified hypericin as a novel inhibitor of spermidine synthase of Leishmania donovani Hypericin has shown significant antileishmanial activity with IC |
| Pagination: | Not Available |
| URI: | http://hdl.handle.net/10603/482076 |
| Appears in Departments: | DEPARTMENT OF BIOSCIENCES AND BIOENGINEERING |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01_fulltext.pdf | Attached File | 12.13 MB | Adobe PDF | View/Open |
| 04_abstract.pdf | 147.26 kB | Adobe PDF | View/Open | |
| 80_recommendation.pdf | 421.26 kB | Adobe PDF | View/Open |
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