Development of fluorescent sensors for reactive nitrogen species like nitri c oxide and nitrite ion

Abstract

Oxidative and nitrosative stress induced by RNS pla y crucial roles in a wide range of physiological processes and are also implicated in various diseas es including cancer and neurodegenerative disorder s Sensitive and selective methods for the detection o f RNS based on fluorescent and luminescent probes a re of great use in monitoring the in vivo production o f these species and elucidating their biological functions There are several requirements for fluor escent NO sensors to be useful i