Xanthine based inhibitors for therapeutics targeting phosphodiesterase 9a

Abstract

Xanthine is a versatile nitrogenous alkaloid The pharmaceutical active nature of xanthine derivatives is widely known for treating various diseases Therefore xanthine can act as structurally rigid scaffold which provides enormous possibility for molecular diversity in drug development process Xanthine based compounds are reported for their non specific phosphodiesterase inhibition however xanthine based inhibitors have not been reported for PDE9A inhibition With introduction of 339 xanthin