Study of microenvironment mediated chemoresistance in chronic myeloid leukemia

Abstract

Chronic Myeloid Leukemia CML is a myelo proliferative disorder in which the leukemic stem cells LSC give rise to abnormally high number of myeloid cells CML is initiated by BCRABL fusion 9 22 q34 q11 which is the result of reciprocal translocation between chromosome 9 and chromosome 22 BCR ABL fusion gene codes for Bcr Abl fusion protein which is a constitutively active tyrosine kinase Tyrosine kinase inhibitors TKIs such as Imatinib mesylate IM is the mainline drug used for the t