Shodhganga : a reservoir of Indian theses @ INFLIBNET
The Shodhganga@INFLIBNET Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access.
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/481120
| Title: | Aptamers for breast cancer protein markers |
| Researcher: | Sett, Arghya |
| Guide(s): | Bora, Utpal |
| Keywords: | Biotechnology and Applied Microbiology Life Sciences Microbiology |
| University: | Indian Institute of Technology Guwahati |
| Completed Date: | 2016 |
| Abstract: | In the present thesis, specific DNA aptamers were screened against breast cancer protein biomarkers Her2 and ER alpha. The aptamers were screened by in-vitro SELEX process from a pool of 1014 number of oligonucleotides. The sensitivity of the candidates were evaluated by isothermal calorimetry and other in-vitro binding studies. To assess the biocompatibility of the selected aptamers, MTT assay was performed in marker positive and negative cancer cell lines and normal cell lines also. Specificit |
| Pagination: | |
| URI: | http://hdl.handle.net/10603/481120 |
| Appears in Departments: | DEPARTMENT OF BIOSCIENCES AND BIOENGINEERING |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01_fulltext.pdf | Attached File | 15.57 MB | Adobe PDF | View/Open |
| 04_abstract.pdf | 132.63 kB | Adobe PDF | View/Open | |
| 80_recommendation.pdf | 667.85 kB | Adobe PDF | View/Open |
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