Studies toward 1 3 enyne cyclization for the synthesis of functionalized pyrroles pyrazoles and thiophenes

Abstract

The thesis contains four chapters The first chapter deliberates the recent developments of alkyne cyclization reactions employing various electrophiles and transition metal catalysts for the construction of diverse heterocycles The second chapter presents the synthesis of tetra and penta substituted pyrroles from 1 3 enynes and amines using molecular iodine via aza Michael addition iodocyclization and oxidative aromatization under mild conditions These results suggests that the electron def