Studies on identification and in vivo function of novel drug target enzymes of leishmania donovani using biomolecular approaches

Abstract

Leishmaniasis is a neglected parasitic disease caused by several species of Leishmania parasite The current drug scenario against this disease is not very good due to poor efficacy high cost and major side effects Moreover there are several reports about resistance against available drugs There is an eminent requirement for drugs with higher efficacy and lower side effects Discovery and validation of novel drug targets are prerequisite for any drug discovery effort In our study we have