Regioselective bromination of substituted 2 hydroxy chalcones and synthesis of fused nitrogen heterocycles

Abstract

The thesis describes a new synthetic protocol for regioselective monobromination of E 1 2 hydroxy 4 6 dimethoxyphenyl 3 aryl 2 propen 1 ones using BDMS Further it also illustrates the synthesis of 7 bromoaurone and 8 bromoflavone derivatives from the brominated products by cyclization on treatment with 0 2 M ethanolic KOH solution The protocol has several advantages such as non hazardous high efficiency and selectivity In addition the thesis also demonstrates the one pot synthesis o