Correlation of Oxidative Stress with Abo Blood Groups in Hypertensive Patients

Abstract

Hypertension is a highly prevalent pathological condition that is considered one of the most relevant cardiovascular risk factors and is an important cause of morbidity and mortality around the world. Even though mechanisms underlying hypertension are not yet fully elucidated, a large amount of evidence shows that oxidative stress plays a central role in its patho-physiology. Oxidative stress can be defined as an imbalance between oxidant and antioxidant molecules and leads to a decrease in nitric oxide bioavailability, which is the main factor responsible for maintaining the vascular tone. The ABO blood group system involves two antigens and two antibodies found in human blood. The two antigens are antigen A and antigen B. The two antibodies are antibody A and antibody B. The antigens are present on the red blood cells and the antibodies in the serum. Regarding the antigen property of the blood all human beings can be classified into four groups, those with antigen A (group A), those with antigen B (group B), those with both antigen A and B (group AB), and those with neither antigen (group O). Apart from their matching role in blood transfusion these specific antigens are known to play an important role in the regulation of various biochemical reactions. Although the interaction of blood groups and disease has been the object of intense studies for more than a century, there are huge gaps in our understanding of the relative levels of oxidative stress in individual blood groups. Since our blood groups and genetically dependent enzymes play an important role in our body function and defense. Therefore these may vary from individual to individual of different blood groups. Hence the present study was carried out to explore any correlation between oxidative stress and ABO blood groups in patients with essential hypertension. The study concluded that hypertensive patients with blood group antigen A and or B are more prone to oxidative stress due to interference of carbohydrate moieties on red cell antigens N-acetyl