Design and synthesis of fluorescent unnatural triazolyl amino acids and constraints molecular scaffold and their application in peptidomimetics

Abstract

In chapter I describe the applications of unnatural amino acids and conformationally constrained small molecule scaffold a review chapter In chapter II We report herein the design and synthesis of microenvironment sensitive fluorescent triazolyl unnatural amino acids UNAA decorated with donor and or acceptor aromatic chromophores via click chemistry The synthesized fluorescent amino acids show interesting solvatochromic characteristic and or intramolecular charge transfer ICT feature as