Synthesis and investigation on water soluble mono aquated and bis aquated gd iii and mn ii complexes as potential mri contrast agents

Abstract

Magnetic resonance imaging MRI is the widely used noninvasive clinical diagnosis modality that provides anatomical tissue images of high spatial resolution The technique is based on 1H NMR signal recording and thus limited by low sensitivity To deal with the issue imaging processes are often accompanied by prior administration of a paramagnetic substance which is known as contrast agents CA Gd III 8220 based stable and water 8220 soluble complexes are most widely studied as CAs because of i