Studies on the interaction of small fluorescent molecules nucleoside with duplex g quadruplex and calf thymus dna

Abstract

It is known so far that DNAs can be good drug targets Long telomeric DNA which forms G quadruplex is also a potential drug target in cancer therapy Hence search of highly specific ligand is important for design of anticancer drugs This not only directs the therapeutic applications but also helps in diagnosis of G rich gene sequence Chapter 2 describes design and synthesis of sovatochromic nucleoside probes for detection of SNPs Naphthalene appended uridine nucleoside utilized for detectio