Studies on recombinant protein and peptides derived from diphtheria toxin

Abstract

Diphtheria toxin DT is a well characterized AB toxin with three independent domains C domain for catalysis and toxicity T domain for translocation through the membrane and R domain or receptor binding domain The toxicity of DT has been investigated extensively and is utilized to create therapeutic agents like immunotoxins which kill cells However the receptor binding ability of DT is not extensively explored and used for therapeutic purposes The receptor of DT is Heparin binding EGF li