Investigations on nanoparticles Detection using advanced Fluorescence and gmr sensors for Biomedical applications

Abstract

A Chip-based Giant Magneto Resistance (GMR) using Magnetic Nano newlineParticles (MNPs) and smartphone-based bio detection have become powerful newlinetools for rapid biomolecule detection and for real-time electrical readout. newlineBiosensors are used for the detection of biological and bio-molecular agents newlinesuch as: virus particles, proteins, bacteria and nucleic acids. In addition, GMR newlinesensors and smartphone-based systems allow for real-time detection of these newlinebio probes. Many researchers have used smartphones for fluorescent newlinedetection. Despite the promising progress, fluorescence detection on newlinesmartphone devices remains a big challenge due to environmental light newlinesources that results in bleaching effect in the target sample. newlineMethods such as: Enzyme-linked immunosorbent assay, Polymerase newlineChain Reaction (PCR), Fluorescent based optical methods, Anisotropic newlineMagneto Resistance (AMR), Hall sensor and Induction method are used for newlinedetecting the bioprobes using nanotechnology. However, these methods take newlinemore time to produce the result and are costly and hence are not affordable for newlinesmall-scale medical diagnosis labs. In recent years, the advanced in electronic newlinedevices and smartphones are emerging as powerful platforms to develop costeffective, newlineportable and readily accessible medical diagnostic devices. The newlinesmartphone-based diagnostic methods hold enormous potential over others newlinedue to their multifunctional and high-quality camera newline