Design synthesis and study of photophysical biophysical properties of small molecular scaffold peptides and fluorescent and#946; lactams

Abstract

This Thesis has a total of five chapters out of which the Chapter 1 is a literature review about the β-hairpin and β-sheet peptidomimetics. This review chapter contains a critical survey of conformationally constrained small molecular scaffold as inducer of particular secondary structure in a peptide, such as β-hairpin and β-sheet peptidomimetics. Chapter 2 includes uracil-di-aza-amino acid (UrAA) as a new family of molecular scaffold with ability to induce β-hairpin structure with H-bonded newline