Design Synthesis and Investigation of Potential Pharmacophores derived from Hybrid based Heterocycles

Abstract

Heterocycles are most significant class of organic compounds and vital scaffolds that are present in most of the natural products, synthetic drugs, agrochemicals, and polymers. Heterocyclic compounds displaying biological properties such as antitubercular, antitumor, antimalarial, anti-HIV, anti-inflammatory, antidepressant, antimicrobial, antidiabetic, antibiotic, antiviral, herbicidal, and insecticidal. More than two third of existing drugs are containing heterocyclic moiety as their structural and functional unit. newlineIn recent years molecular hybridization is emerging as a new strategy within medicinal chemistry and drug discovery which involves the combination of two distinct pharmacophores into a single molecule. This molecular hybridization concept for the formation of hybrid drugs has gained more interest in which two or more bioactive pharmacophores are linked covalently to comprise synergistic effect. The significance of hybrid heterocycles produced by using molecular hybridization criteria is to activate different targets by a single molecule, consequently increasing therapeutic efficiency further to improve the bioavailability. newlineThe widespread applications of hybrid heterocycles have promoted us to work in the area of their designing and synthesis with pharmaceutical interest. In this proposed work different hybrid based heterocycles were synthesized by applying green methodology effect. All the synthesized hybrid scaffolds were characterized by spectral analysis and evaluated for their biological activities. newlineChapter 1 newlineWe have described a new convenient approach for the synthesis of substituted thiazolopyrimidines. The present strategy delivers the use of silica supported sodium carbonate (SSC) as a recyclable heterogeneous catalyst in PEG- 400 solvent. The described synthetic path bids an easy access for the synthesis of titled compounds through green chemistry protocols. The newly synthesized derivatives were characterized by spectroscopic techniques and also evaluated for their antitubercular newlineAbstract newline