Connexin 43 mediated communication in cancer gene therapy

Abstract

Cancer cells are known to lack regulation of cell proliferation due to the aberrant behavior of a myriad of signaling pathways It is a disease of 339 abnormal homeostasis mediated by defects in intra extra and intercellular forms of communications Intercellular communication between cells is achieved with the help of gap junctional intercellular communication GJIC GJIC plays a crucial role in maintaining cell cell homeostasis by keeping growth control signals at equilibrium among GJIC