Phytochemical Analysis and Anti Obesity Activity of Herbal Extracts

Abstract

Institute of Pharmacy, Nirma University i newlinePhytochemical Analysis and Anti-Obesity Activity of Herbal Extracts newlineAbstract newlineObesity is one of significant life style disorders which may lead to disagreeable effects newlineon cholesterol, triglycerides, blood pressure and insulin resistance and ultimately newlineincreases the risk of various adverse conditions like stroke, ischemic heart disease, newlinecoronary artery disease and Type 2 diabetes. Obesity is one of the most prevalent health newlineconcerns among all age groups and populations worldwide, resulting in a significant newlineincrease in mortality and morbidity related to metabolic disorders. The present newlineinvestigation was undertaken to explore anti-obesity activity of methanolic extracts of newlineaerial parts of Fagonia cretica L. and seeds of Wrightia tinctoria R. Br. along with their newlinephytochemical analysis. Both the plant samples were procured and evaluated newlineaccording to Ayurvedic Pharmacopoeia of India. The qualitative phytochemical newlinestudies of prepared extract and fractions showed presence of flavonoids, saponins, newlinephenolics, alkaloids, and carbohydrates. Cafeteria diet (CD) induced obesity model newlinewas used to evaluate anti-obesity activity. Improvement in various metabolic newlineindicators like daily food consumption, body weight, lipid profile, fecal fat content and newlinefat pads was seen after treatment with methanolic extracts of both plant materials. newlineIn vivo anti lipolytic action of methanolic extracts of both plant materials were studied newlineby using lipid emulsion as tracer substance. At 3 and 4 h after administration of lipid newlineemulsion, the plasma triglyceride concentrations were significantly lowered in group newlineadministered higher doses of methanolic extracts of both plant materials. newlineTargeting one or more enzymes involved in lipid metabolism can be selective for newlineevaluation of anti-obesity action of drug. The n-butanol fraction of methanolic extracts newlineof Fagonia cretica L. and n- hexane fraction of methanolic extracts of Wrightia newlinetinctoria R. Br. showed highest pancreatic lipase inhibitory activity. The e