A comparative study of beta trace proteins in chronic kidney disease

Abstract

newline A general terminology adopted to represent any impairment of kidney s structures or functions is chronic kidney diseases (CKDs) which are linked with high chances of failure of kidneys in its final stages. A GFR of lt60millilitre per minute per 1.73 m2 indicates the occurrence of CKDs, which is characterized by altered kidney s functions. According to several studies, BTP have the potential to be employed as serum indicators in the diagnosis of renal function. In the present investigation, 100 people were selected who were suffering with CKDs as case group while 100 healthy individuals were taken as control group. The investigation was conducted at Government Medical College, Rajouri after getting approval from IEC, GMC Rajouri and Ethics committee (EC), Adesh University, Bhatinda. The age range was above 18 years. In all subjects, age, gender, height, body weight, and BMI were recorded as anthropological and demographical data. SBP and DBP were also measured in all subjects. Fasting blood glucose, urea, creatinine and beta trace proteins were measured in both cases and controls using standard protocols. The results showed that serum BTP level was increased two times (from 32.97±10.92 and#956;g/ml to 63.47±27.07 and#956;g/ml) in CKD patients than control individuals while it was observed independent to gender. The correlation of serum BTP level with fasting blood glucose level, serum creatinine level, serum urea level, and creatinine clearance rate was also determined by calculating Pearson s correlation coefficient. Results revealed that serum BTP level was positively correlated with fasting blood glucose level (0.98), serum urea level (0.99), and serum creatinine level (0.99) while it was found to be negatively correlated with creatinine clearance rate (-0.99). The results of the present investigation concluded that serum beta trace protein may be a useful and more reliable biomarker in early diagnosis of magnitude of chronic kidney diseases and may have its place beside serum creatinine as an alternative endogenous GFR ma