Strategies and approaches for mechanistic understanding of bacterial ribosome assembly

Abstract

Ribosomes are large ribonucleoprotein complexes that catalyze protein synthesis Decades of efforts directed towards understanding ribosome structure and function have revealed crucial insights into the working of these complex molecular machines In parallel attempts to trace their biogenesis have uncovered an orchestrated interplay between synthesis and the hierarchical assembly of ribosomal components However due to the large size of the ribosomal RNA it s folding and the recruitment of r