Studies on inclusion complexes of thiazolidinones containing benzothiazolyl moiety with and#946; cyclodextrin

Abstract

4-Thiazolidinone is the derivative of thiazoline having carbonyl newlinegroup(C=O) at position-4. Thiazoline moiety is present in the structure of newlinepenicillin. Studies in the interesting field of structure activity relationship newlineof such compounds in recent years have brought out many revealing newlinefacts, but all such compounds of 4-Thiazolidinones are important class of newlinepharmacophores that appear comprehensively in diverse types of newlinepharmaceutical agents, usually implicated in biochemical processes and newlineexhibit diversity of pharmacological activities. Some important activities newlineinclude antibacterial, antifungal, antiviral and antioxidant activities etc. newlineBut all such compounds have poor solubility in polar medium and their newlineuses may result in local tissue irritation, interference with sound healing process, hypersensitivity reactions, systemic toxicity etc. Besides this, newlinelower solubility may reduce their bio-accessibility thereby reducing drug newlineefficiency. The solubility and bio-accessibility of these compounds can be newlineenhanced significantly by forming inclusion complexes with a nontoxic newlineoligosaccharide, and#946;-cyclodextrin. Out of all known cyclodextrins, and#946;- newlinecyclodextrin is usually considered better for inclusion complex formation newlinebecause it is non-toxic, cheaper, easily available and highly stable newlinetowards heat and oxidation. In the present work two organic compounds namely 2- newline(Benzothiazolyl-2 )hydrazono-3-phenyl-5-arylidene-4-thiazolidinone and newline2-(Benzothiazolyl-2 )hydrazono-5-arylidene-4-thiazolidinone and their newlinederivatives have been prepared. The formation of the compounds has newlinebeen ascertained spectrometrically. In order to increase solubility of the newlinesynthesized compounds, their inclusion complexes have been prepared newlinewith and#946;-cyclodextrin subsequently studying their aqueous phase solubility. newline