Studies on the Ni Catalyzed Synthesis of Tertiary Amides and Pd Catalyzed Synthesis of and#945; Naphthol Based Triarylmethanes Ortho Arylated D Phenylglycine Methyl Esters and and#946; Arylated Keto Acids

Abstract

A literature survey revealed that the N-arylation and C-N bond formations have been well studied newlineusing Cu or Pd catalysts. Notably, the N-arylation and C-N bond formations have not been reported newlineusing Ni catalysts and a part of this thesis deals on the usage of nickel catalyst for the synthesis of newlinetertiary amides via N-arylation and C-N bond formation. Next, the C-C bond formation by Heck newlinecoupling reactions has significantly attracted the attention of chemists. Aryl sulphonyl chlorides newlinehave also been introduced in the place of aryl halides for performing the Heck reactions. In this newlineline, a part of this thesis work deals on synthesis of and#945;-naphthol-based triarylmethanes via Heck newlinecoupling reaction. In recent years, the transition metal-catalyzed directed C-H functionalization newlinereactions have emerged as one of the important synthetic organic transformations. In this line, a newlinepart of this thesis deals on the Pd-catalyzed bis-arylation of ortho C(sp 2 )-H bonds of D-(-)- newlinephenylglycine methyl esters and also and#946;-C(sp 3 )-H arylation of and#949;-, and#950;-, and#951;-keto acids. newlineThis thesis entitled Studies on the Ni-Catalyzed Synthesis of Tertiary Amides and Pd-Catalyzed newlineSynthesis of and#945;-Naphthol-Based Triarylmethanes, Ortho-Arylated D-(-)-Phenylglycine Methyl newlineEsters and and#946;-Arylated Keto Acids. newline