Shodhganga : a reservoir of Indian theses @ INFLIBNET
The Shodhganga@INFLIBNET Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access.
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/472147
| Title: | Destabilization of Alzheimers Amyloid and#946; Fibrils by Natural Compounds An All Atom Molecular Dynamics Simulation Study |
| Researcher: | Gupta, Shivani |
| Guide(s): | Dasmahapatra, Ashok Kumar |
| Keywords: | Engineering Engineering and Technology Engineering Chemical |
| University: | Indian Institute of Technology Guwahati |
| Completed Date: | 2023 |
| Abstract: | Alzheimer s Disease (AD) which is a progressive, neurodegenerative and geriatric disease is multi-faceted in nature with genetic, environmental and some unknown mechanism associated with it. The main culprit behind the etiology of the disease is believed to be the extraneuronal senile plaques made up of Amyloid-Beta (Aand#946;) proteins and intraneuronal neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein. Amongst these two, Aand#946; fibrils have been reported to be the principal clinical hallmark due to its direct involvement in the neurotoxicity and degeneration leading to AD. newline |
| Pagination: | |
| URI: | http://hdl.handle.net/10603/472147 |
| Appears in Departments: | DEPARTMENT OF CHEMICAL ENGINEERING |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01_fulltext.pdf | Attached File | 14.42 MB | Adobe PDF | View/Open |
| 04_abstract.pdf | 146.28 kB | Adobe PDF | View/Open | |
| 80_recommendation.pdf | 203.63 kB | Adobe PDF | View/Open |
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