Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/471678
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DC FieldValueLanguage
dc.coverage.spatialPharmacy
dc.date.accessioned2023-03-22T09:16:09Z-
dc.date.available2023-03-22T09:16:09Z-
dc.identifier.urihttp://hdl.handle.net/10603/471678-
dc.description.abstractDepression is a complex psychiatric disorder characterized by the symptoms such as loss of energy, low self-esteem, poor concentration, anhedonia, low energy, sleep disturbances, loss of appetite, suicidality, etc. Depression related behavior in experimental animals can be assessed using behavioral paradigms including tail suspension test (TST) and forced swim test (FST). Immobility developed by the animals in these paradigms served as an indicator of behavioral despair which presents the condition analogous to depression in humans. Various neurochemicals such as serotonin, glutamate, NO, etc. are involved in the regulation of depression related behavior. The enhancement of serotonergic signaling confer the antidepressant like effect. Various categories of the drugs are used to treat depression but selective serotonin reuptake inhibitor (SSRIs) are used as the first line treatment for depression. However, SSRIs treatment has been shown to impose the risk of suicidality, sexual dysfunction, akathisia, GIT disturbance, insomnia etc. Further, SSRIs treatment takes weeks to impose their clinical therapeutic effect in the prescribed patients but only 50% of prescribed patients respond to these drugs. These findings suggested the need of safer and more efficient antidepressant agents. Therefore, both the prescriber and patients look for the newer and safer therapeutic agents for the effective management of depression.
dc.format.extent121
dc.languageEnglish
dc.relation131
dc.rightsuniversity
dc.titleInvestigation Of Some Enzyme Modulators For Their Antidepressant Potential
dc.title.alternative
dc.creator.researcherSushma Maratha
dc.subject.keywordClinical Pre Clinical and Health
dc.subject.keywordPharmacology and Pharmacy
dc.subject.keywordPharmacology and Toxicology
dc.description.notePharmacy
dc.contributor.guideVijay Sharma
dc.publisher.placeGurugram
dc.publisher.universitySGT University
dc.publisher.institutionDepartment of Pharmacy
dc.date.registered2017
dc.date.completed2023
dc.date.awarded2023
dc.format.dimensionsA4
dc.format.accompanyingmaterialDVD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Pharmacy

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01_title.pdf.pdfAttached File33.93 kBAdobe PDFView/Open
02_prelim pages.pdf.pdf263.31 kBAdobe PDFView/Open
03_content.pdf.pdf25.97 kBAdobe PDFView/Open
04_abstract.pdf.pdf72.71 kBAdobe PDFView/Open
05_chapter 1.pdf.pdf144.58 kBAdobe PDFView/Open
06_chapter 2.pdf.pdf180.4 kBAdobe PDFView/Open
07_chapter 3.pdf.pdf144.11 kBAdobe PDFView/Open
08_chapter 4.pdf.pdf139.56 kBAdobe PDFView/Open
09_chapter 5.pdf.pdf524.05 kBAdobe PDFView/Open
10_annexures .pdf.pdf1.84 MBAdobe PDFView/Open
11_chapter 6.pdf.pdf527.95 kBAdobe PDFView/Open
12_chapter 7.pdf.pdf481.18 kBAdobe PDFView/Open
13_chapter 8.pdf.pdf194.57 kBAdobe PDFView/Open
80_recommendation.pdf322.58 kBAdobe PDFView/Open


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