Modulation of amyloid aggregation and cancer theranostic using luminescent conjugate materials

Abstract

Protein aggregates are associated with neurodegenerative diseases and they are increasingly recognized as important in cancer and diabetes This thesis focuses on small molecule and polymer based luminescent materials on amyloid aggregation in order to modulate amyloid aggregates with an additional feature of self indication Mutual aggregation between amyloid and modulator becomes predominant compared to self aggregation due to oligoblocking and or formation of co aggregates A versatile polyf