Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/468889
Title: A Mechanistic Study of Endothelial Dysfunction and Cellular Senescence in Cardiovascular Disease
Researcher: Vijay, R
Guide(s): Venkataraman, P
Keywords: Genetics and Heredity
Life Sciences
Molecular Biology and Genetics
University: SRM Institute of Science and Technology
Completed Date: 2022
Abstract: Plasma concentrations of asymmetric dimethylarginine (ADMA), homocysteine (HCY) and s-adenosylhomocysteine (SAH) are well-established cardiovascular risk factors. Besides, these analytes have a critical role in influencing the diseases associated with elevated oxidative stress (OS) such as diabetes, hypertension and certain cancers. Interestingly, SAH is an endogenous inhibitor of a group of enzymes, methyltransferases (MTs), which are involved in the biosynthesis of ADMA. In this regard, logically, when SAH levels are elevated, due to its MT inhibitory effect, ADMA levels should be compromised. However, in coronary artery disease (CAD), there is an elevation of ADMA, HCY and SAH. This suggests that there could a mechanism which over-rides the inhibitory effect of SAH, which causes ADMA elevation newline
Pagination: 
URI: http://hdl.handle.net/10603/468889
Appears in Departments:Department of Genetic Engineering

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02_preliminary page.pdf409.77 kBAdobe PDFView/Open
03_content.pdf310.29 kBAdobe PDFView/Open
04_abstract.pdf269.02 kBAdobe PDFView/Open
05_chapter 1.pdf277.55 kBAdobe PDFView/Open
06_chapter 2.pdf296.65 kBAdobe PDFView/Open
07_chapter 3.pdf439.03 kBAdobe PDFView/Open
08_chapter 4.pdf886.54 kBAdobe PDFView/Open
09_chapter 5.pdf1.01 MBAdobe PDFView/Open
10_chapter 6.pdf161.36 kBAdobe PDFView/Open
11_annexures.pdf2.02 MBAdobe PDFView/Open
80_recommendation.pdf198.48 kBAdobe PDFView/Open
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