New Approach for Synthesis of Pyridine Analogues Against Methicillin Resistant Staphylococcus Aureus

Abstract

Heterocyclic chemistry is the most challenging and rewarding field of study amongst various other branches of chemistry. Heterocyclic compounds are cyclic compounds containing at least one heteroatom in their ring. It is well known that N-heterocycles exhibited promising antibacterial activity. Because their structural subunits are found in many natural products such as vitamins, hormones, and antibiotics. newlineThe N-heterocyclic compounds are some of the most important building blocks in organic and medicinal chemistry. Among that, pyridine continues to play a vital role in developing human medicines. This ring is utilized in more than 100 drugs. Due to the diversity of these analogs in the therapeutic response profile, many researchers have been working to explore synthetic routes for this skeleton. newlineStaphylococci are a group of Gram-positive bacteria, 14 species are known to cause human infections, but the vast majority of infections are caused by only three of them. They are Staphylococcus aureus, Staphylococcus epidermis, and Staphylococcus saprophyticus. Among these most dangerous species is Staphylococcus aureus. In the present investigation, a series of pyridine analogs were synthesized by a new approach, and they were characterized by different spectral techniques such as 1H-NMR, 13C-NMR, FT-IR, and HRMS. Evaluated for antibacterial study against MRSA and validated by molecular docking and dynamics simulation studies. newlineThe work presented in the thesis entitled New Approach for Synthesis of Pyridine Analogues against Methicillin-Resistant Staphylococcus aureus for the Ph.D. degree has been divided into four chapters. newline CHAPTER -1: INTRODUCTION AND LITERATURE SURVEY newline CHAPTER-2: DEVELOPMENT OF NEW SYNTHETIC ROUTE FOR THE SYNTHESIS OF PYRIDINE CHALCONES AS ANTI-MRSA AGENT newline CHAPTER-3: ONE-POT SYNTHESIS OF PYROZOYLPYRIDINE DERIVATIVES TO TACKLE MRSA. newline CHAPTER-4: SYNTHESIS OF PYRIDINE COUPLED PYRIMIDINONES AND PYRIMIDINOTHIONES: ANTIBACTERIAL ACTIVITY AGAINST MRSA newline