Bactericidal potency and extended plasma half life of stereochemically diversified polypeptide constructs

Abstract

Conventional peptide design only guarantees functional group constitution by opting specific amino acid sequence and not their spatial orientation because peptide molecules are very fluxional and its conformation is subjected to external flux This is principally due to the isotactic stereochemistry of the peptide chain Stereo chemical engineering of peptide main chain offers expansion of design space of a typical sequence possibly offering greater conformational rigidity by avoiding the 732