Biochemical markers and protein analysis in colorectal cancer

Abstract

Abstract: newlineColorectal cancer also referred as cancer of colon and rectum is one of the major newlinecauses of cancer death worldwide. The incidence, mortality and prevalence rates are newlineconsistently higher, although the incidence is higher in males compared to females. In India newlineColorectal cancer is the fifth most common cancer and frequently encountered newlinepathophysiological condition that imposes heavy burden on individuals, families and also newlinehealthcare system. newlineThe aim of the present study is to elucidate biochemical markers and protein analysis in newlinecolorectal cancer. The objectives are newlinea) To determine the impact of tumor markers on cancer specific survival CEA newline(Carcinoembryonic Antigen) and CA 19-9 (carbohydrate antigen19-9) were estimated. newlineb) To perform a comprehensive comparison of protein factors for prognostic value of tumor newlineamong the CRC patients, the level of TIMP-1(tissue inhibitor of metalloproteinase -1), MIF newline(macrophage migration inhibitor factor) proteins and Prolactin were determined. newlinec) To examine the relationship between clinicopathological characteristics and relation newlinebetween inflammatory response the levels of C- reactive protein, fecal Hemoglobin, CBC, lipid newlineprofile, Amylase and Lipase were analyzed. newlined) To examine the relationship between comorbidity in CRC patients Serum bilirubin and ratio newlineof ALT/AST were determined. newlineThe outcome of the study shows that tumour markers CEA and CA19-9 are significant newlineprognostic indicator in CRC patients. Protein markers elucidate that exceptionally, high serum newlinelevels of TIMP-1 and MIF proteins may have strong association with great prognosis of CRC. newlineThe markers like CEA, CA19-9, Fecal Hemoglobin have more specificity compared to sensitivity newlineand efficiency. Whereas markers like CRP, MIF, TIMP-1 and prolactin are showing excellent newlinesensitivity as compared to specificity. The elevated levels of CRP in colorectal cancer patients newlinehave been associated with tumor stages and recurrence and reduced survival rate.