Effect of chocolate brown ht on some male and female reproductive variables in rat a molecular physiological study

Abstract

Chemically Chocolate Brown HT is a synthetic bis-azo dye and gives persistent newlinereddish brown color to the product where it is used. It is used heedlessly in food newlineindustries to impart color in different food products like ice-cream, candies, dessert newlinemixes and beverages etc. Experiments with Chocolate Brown HT in albino rat model newlineshowed impairment in the male and female reproductive systems functions in this newlinestudy. Significant alterations in estrous cycle physiology, decrease in male and female newlinehormone level (leutinizing hormone, follicle stimulating hormone, testosterone and newlineestradiol), decrease in the number of normal motile sperms in epididymis, newlinehistoarchitectural changes in the testis and uterus due to potentiation of oxidative newlinestress, and significant inhibition in the contraction of uterine smooth muscle through newlineepinephrine/norepinephrine mediated and#946; adrenergic and nitric oxide (NO) mediated newlinesoluble guanylyl cyclase (sGC) signaling pathways have been observed in Chocolate newlineBrown HT exposed male and female rats. So, considering the results as stated above, newlineit may be concluded that Chocolate Brown HT may be considered as a potential newlinereproductive toxin due to its probable deleterious impacts on male and female newlinereproductive systems functions as observed in albino rat model. newline