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http://hdl.handle.net/10603/460146
Title: | Analyses of transcription factors from pathogenic organisms elucidation of their involvements in disease developments |
Researcher: | Chowdhury, Nilkanta |
Guide(s): | Bagchi, Angshuman |
Keywords: | Biochemical Research Methods Biology and Biochemistry Life Sciences |
University: | University of Kalyani |
Completed Date: | 2020 |
Abstract: | The main goal of the thesis titled and#8213;Analyses of transcription factors from pathogenic newlineorganisms - elucidation of their involvements in disease developmentsand#8214; is to analyze the newlinemechanism of DNA-protein interactions and how the DNA-protein interactions are newlineassociated with diseases. DNA-protein interactions play vital roles in many of the newlinebiological processes. The central dogma of molecular biology relies on the proper binding newlineinteractions between the DNA and the protein [1]. The binding of proteins to DNA lead to newlinethe generation of different types of virulence factors from pathogenic organisms. For my newlinestudy, I used the pathogenic organism Pseudomonas aeruginosa. Pseudomonas aeruginosa newlineis an opportunistic human pathogen [2]. The organism attacks immune-compromised newlinepatients and spreads secondary infections [3]. The severities of the infections are such that newlinenearly 60% of deaths in hospitals are caused due to secondary infections by the organism newline[4]. The organism codes for highly poisonous hydrogen cyanide (HCN) by the enzyme newlineHCN synthase. The enzyme is transcribed by the genes of the operon hcnABC [5]. The newlinetranscription of the genes of the operon is mediated by three proteins called LasR, ANR and newlineRhlR [6, 7]. The genetics of the aforementioned transcription process is well understood. newlineHowever, till date, the molecular mechanism of the process is not known. In my thesis newlinework, I tried to analyze and predict the molecular mechanism of the transcription process as newlineit has not yet been deciphered. Therefore, I extracted the existing data pertaining to the newlinehcnABC operon and used and analyzed them with the help of existing bioinformatics tools to newlinecome up with a suitable computational model to interpret the molecular mechanism of the newlinesynthesis of HCN from hcnABC operon newline |
Pagination: | vi, 210p |
URI: | http://hdl.handle.net/10603/460146 |
Appears in Departments: | Biochemistry and Biophysics |
Files in This Item:
File | Description | Size | Format | |
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01_tittle.pdf | Attached File | 545.37 kB | Adobe PDF | View/Open |
02_declaration.pdf | 879.6 kB | Adobe PDF | View/Open | |
03_certificate.pdf | 199.16 kB | Adobe PDF | View/Open | |
04_acknowledgement.pdf | 100.76 kB | Adobe PDF | View/Open | |
06_chapter 1.pdf | 1.95 MB | Adobe PDF | View/Open | |
07_chapter 2.pdf | 3.11 MB | Adobe PDF | View/Open | |
08_chapter 3.pdf | 2.26 MB | Adobe PDF | View/Open | |
09_chapter 4.pdf | 1.67 MB | Adobe PDF | View/Open | |
10_chapter 5.pdf | 1.23 MB | Adobe PDF | View/Open | |
11_chapter 6.pdf | 2.01 MB | Adobe PDF | View/Open | |
12_chapter 7.pdf | 1.76 MB | Adobe PDF | View/Open | |
14_list of publication.pdf | 278.34 kB | Adobe PDF | View/Open | |
15_list of abberviations.pdf | 7.61 kB | Adobe PDF | View/Open | |
16_abstract.pdf | 673.25 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 278.34 kB | Adobe PDF | View/Open |
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