Study on the antimicrobial and antibiofilm activities of Bacoside A and Reserpine against certain selected bacterial strains of human health concerns

Abstract

It was apparent by the end of the 1980s that the victory against the newlinethreats of bacterial pathogens on public health was a phantasm, with the faster newlinedevelopment of resistant strains than the discovery of a new drug. As a newlineconsequence, the remedial services were in the backfoot position of being on the newlinelosing side of this never-ending evolutionary war. Humans also started to newlineovercome this alarming situation by means of various scientific researches and newlinedevelopments. As a part of that project, the pharmaceutical industry responded newlineimmediately by investing in the development of synthetic antibiotics. Various newlinehigh-tech approaches were ushered to form new alternative strategies based on newlinehigh throughput screening, genomics study, combinatorial chemistry and newlinerational drug design. The quest for new antibiotics to overcome resistance newlineproblems has long been a top research priority for the pharmaceutical industry. newlineHowever, the resistance problems remained due to the enhanced inherent risk newlineof toxicity owing to the high doses of antibiotics needed to achieve efficacy. In newlineaddition, overuse, underuse and general misuse of antibiotics by common newlinepeople had worsened the scenario by disseminating the antibiotic-resistant newlinebacterial strains among the healthy populations. As a result, antibiotics newlineresearch went into severe decline and many larger pharmaceutical companies newlinewere unable to find any profit from this investment and left the field altogether. newline